Journal of Bioscience and Bioengineering  coverThe Journal of Bioscience and Bioengineering (JBB) is an international journal devoted to the rapid publication of papers describing original research in the field of biotechnology. JBB encourages and publishes new concepts in technology/methodology that significantly advance the understanding of bioscience and bioengineering and contribute to the development of chemical, pharmaceutical, medical, food, and agricultural industries. The Editorial Committee makes its best efforts to provide expeditious, rigorous and fair peer-review, ensuring the high quality of articles published in JBB.

JBB is published monthly (2 vols. in 12 issues) by the Society for Biotechnology, Japan and distributed outside Japan by Elsevier. Online version is available in ScienceDirect. The journal was first published in 1923, originally being named Jyozogaku Zasshi (in Japanese) and then renamed Hakkokogaku Zasshi (in Japanese) (1944), Journal of Fermentation Technology (1973), and Journal of Fermentation and Bioengineering (1989). It was given the current name in 1999. JBB has established itself as one of the most influential biotechnology journals and is now highly appreciated by scientists throughout the world.

JBB is abstracted/indexed in BIOSIS, Chemical Abstracts, Current Contents, EMBASE/Excerpta Medica, Elsevier BIOBASE/Current Awareness in Biological Sciences, ISI Biotechnology Citation Index, and MEDLINE/PubMed.

Print ISSN 1389-1723
Online ISSN 1347-4421
Impact Factor: 2.894 (2020)

Vol. 132 Cover Illustration

Phagocytosis of apoptotic cancer cells with dendritic cells is an important event for cancer immunology and immunotherapy. So far, phagocytosis has been investigated by flow cytometric analysis of the mixture of fluorescence-stained cancer and dendritic cells. However, there is limited information that can be obtained by quantifying fluorescence intensity. Satoshi Yamaguchi and Akimitsu Okamoto in The University of Tokyo made a single-cell array of the phagocytosis mixture including red-stained dendritic cells, green-stained apoptotic cancer cells and cancer-phagocytizing dendritic cells. This image shows a part of the array and gives information about the ratio of cell pairs in various phagocytic states such as phagocytosis-starting pairs, partially phagocytizing ones and fully phagocytizing ones. This method allows for accurate evaluation of phagocytosis efficiency and reliable isolation of vaccinated dendritic cells.

This image was taken by Satoshi Yamaguchi in Okamoto group, Research Center for Advanced Science and Technology, The University of Tokyo ( (Copyright@2021 The Society for Biotechnology, Japan).

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